April 2018 cover
As the terrestrial human footprint continues to expand, the amount of native forest that is free from significant damaging human activities is in precipitous decline. The remaining intact forests, such as the pictured Danum Valley, Borneo, should be accorded urgent conservation priority because of their value for biodiversity, carbon sequestration and storage, water provision, and the maintenance of indigenous cultures and human health. Image by Liana Joseph.

From 'The exceptional value of intact forest ecosystems'. Watson et al., Nature Ecology & Evolution 2; 599-610 (2018).
Comments
All ecosystems in the biosphere whether on land, in fresh water, or in salt water are threatened by the human footprint. Thus people are gradually destroying their life support system on Earth.